Correlation of maternal - placental circulation ultrasound parameters with placental hypoxia and oxidative stress in patients with preeclampsia

摘要

Objective: To study the correlation of maternal - placental circulation ultrasound parameterswith placental hypoxia and oxidative stress in patients with preeclampsia. Methods: Patientswith preeclampsia who gave birth in Shandong jiaotong hospital between March 2015 andFebruary 2017 were select as the PE group of the study, and the healthy pregnant women whogave birth in the hospital during the same period were selected as the control group of thestudy. Color Doppler ultrasonography was done in the 23-26 weeks of pregnancy to determinethe uterine spiral artery PI, RI and S/D levels; after delivery, the placenta was collected todetermine the expression of hypoxia-induced apoptosis indexes, cell invasion molecules andoxidative stress molecules. Results: Uterine spiral artery PI, RI and S/D levels of PE groupwere significantly higher than those of control group; TXNIP, NLRP3, ASC, Caspase-1, Nrf-2,HO-1 and NQO-1 mRNA expression in placenta tissue of PE group were significantly higherthan those of control group and positively correlated with uterine spiral artery PI, RI and S/Dlevels while CatL, CatB, uPA and LAMA4 mRNA expression were significantly lower thanthose of control group and negatively correlated with uterine spiral artery PI, RI and S/D levels.Conclusion: The increase of maternal - placental circulation blood resistance in patients withpreeclampsia will result in the placental hypoxia, and aggravate the apoptosis and oxidativestress.