Effect of Tegafur Gimeracil Oteracil Potassium Capsule + Kangai injection + intensity-modulated radiation therapy on the cellular malignant biological processes in advanced cervical cancer lesion

摘要

Objective: To study the effect of Tegafur Gimeracil Oteracil Potassium Capsule + Kangaiinjection + intensity-modulated radiation therapy on the cellular malignant biological processesin advanced cervical cancer lesion. Methods: Patients who were diagnosed with advancedcervical cancer in the Second People Hospital of Banan District Chongqing between April2015 and March 2017 were selected and divided into two groups, group A received TegafurGimeracil Oteracil Potassium Capsule + Kangai injection + intensity-modulated radiationtherapy, and group B received cisplatin + intensity-modulated radiation therapy. Serumcontents of tumor markers, tumor invasion molecules and tumor proliferation molecules oftwo groups of patients were detected before treatment as well as 2 weeks and 4 weeks aftertreatment. Results: Serum E-cad, STMN1, Fas and p53 levels of both groups of patients 2weeks and 4 weeks after treatment were significantly higher than those before treatment whileTSGF, TK1, SCC-Ag, CA125, OPN, MMP9, NGAL, CyclinE, CyclinD1 and PCNA levelswere significantly lower than those before treatment, and serum E-cad, STMN1, Fas and p53levels of group A 2 weeks and 4 weeks after treatment were significantly higher than those ofgroup B while TSGF, TK1, SCC-Ag, CA125, OPN, MMP9, NGAL, CyclinE, CyclinD1 andPCNA levels were significantly lower than those of group B. Conclusion: Tegafur GimeracilOteracil Potassium Capsule + Kangai injection + intensity-modulated radiation therapy foradvanced cervical cancer can induce cancer cell apoptosis and inhibit cancer cell proliferationand invasion.