Effects of doxofylline combined with Dingzhang Decoction on AECOPD and its influence on NLRP3 mRNA and TLR4-MyD88 pathway

摘要

Objective: To investigate the effect of doxofylline combined with Dingzhang Decoctionon acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and its effecton NLRP3 mRNA and TLR4MyD88 pathway. Methods: 120 patients with AECOPDfrom May 2017 to June 2018 were randomly divided into two groups (n=60). The controlgroup was treated with doxofylline, and the observation group was treated with DingzhangTangdingzhang in the control group. Blood gas index and lung function index were comparedbetween the two groups. Serum interleukin-1 (IL-1), interleukin-18 (IL-18) and peripheralblood lymphocyte NLRP3 mRNA and TLR4MyD88 pathway were detected and compared.Protein expression level. Results: The effective rate of the observation group was significantlyhigher than that of the control group (P0.05), and it was significantly decreased after treatment (P0.05), and significantlydecreased after treatment (P0.05). The levels of TLR4 and MyD88 in peripheral bloodlymphocytes of the observation group were significantly lower than those of the control group(P0.05). Conclusion: Dingzhang Decoction combined with doxofylline has a better clinicaleffect on AECOPD patients, which can better improve blood gas index and lung function.Dingzhangtang significantly inhibited the TLR4-MyD88 pathway in lymphocytes and downregulatedthe level of NLRP3 mRNA.