Application value of color Doppler ultrasound in the detection of hemodynamic change in patients with chronic kidney disease

摘要

Objective: To study the trauma and bone metabolism after internal absorbable screw andmetal screw fixation treatment of tibia-fibula fracture. Methods: 78 patients with tibia-fibulafracture who received internal fixation surgery in our hospital between May 2013 and October2015 were selected and randomly divided into absorbable group and metal group (n=39) whoaccepted internal absorbable screw fixation and internal metal screw fixation respectively. 3d after operation, serum was collected to determine the levels of inflammatory factors, painmediators, stress hormones and bone metabolism indexes. Results: Serum inflammatorymediators procalcitonin (PCT), Resistin, C-reactive protein (CRP), interleukin-6 (IL-6), andtumor necrosis factor-α (TNF-α), pain mediators substance P (SP), prostaglandin E2 (PGE2)and NPY, stress hormones norepinephrine (NE), epinephrine (E) and cortisol (Cor) as wellas bone resorption marker molecules C-terminal telopeptides of type I collagen (CTX-I)and C-terminal telopeptides of type II collagen (CTX-II) levels of absorbable group weresignificantly lower than those of metal group (P0.05) while bone formation marker moleculesN-MID osteocalcin (N-MID) and N-terminal propeptide of procollagen type I (PINP) levelswere significantly higher than those of metal group (P0.05). Conclusions: The trauma degreeof internal absorbable screw fixation treatment of tibia-fibula fracture is weaker than that ofinternal metal screw fixation, and the bone metabolism activity is better than that of internalmetal screw fixation.