Effect of adjuvant salvia miltiorrhiza and ligustrazine therapy on renal function, renal blood perfusion as well as CTGF and TGF-β1 content in patients with chronic renal failure

摘要

Objective: To analyze the effect of adjuvant salvia miltiorrhiza and ligustrazine therapy onrenal function, renal blood perfusion as well as connective tissue growth factor (CTGF) andtransforming growth factor (TGF)-β1 content in patients with chronic renal failure. Methods:80 patients with chronic renal insufficiency treated in our hospital between March 2013 andMarch 2016 were selected for study and randomly divided into observation group (n=40)and control group (n=40). Control group received conventional therapy and observationgroup received conventional + adjuvant salvia miltiorrhiza and ligustrazine therapy. After 3months of treatment, differences in renal function indexes, illness-related indexes, renal bloodperfusion, CTGF and TGF-β1 content, and so on of two groups of patients were determined.Results: After 3 months of treatment, serum urea nitrogen (BUN), serum creatinine (Scr),β2 microglobulin (β2-MG), intermedin (IMD), fibroblast growth factor 23 (FGF23),cystatin C (CysC), CTGF and TGF-β1 content as well as 24 h urine albumin excretion rate(UAER) level in urine of observation group were significantly lower than those of controlgroup (P＜0.05) while glomerular filtration rate (GFR) level and serum adiponectin (APN)content were significantly higher than those of control group (P＜0.05); renal perfusionparameters renal cortex Tmax (ATc) and medulla Tmax (ATm) levels of observation groupwere significantly lower than those of control group while cortex peak intensity change (ΔAc),medulla peak intensity change (ΔAm) and peak intensity (PI) levels were significantly higherthan those of control group. Conclusions: Adjuvant salvia miltiorrhiza and ligustrazine therapycan effectively control the overall condition of patients with chronic renal failure, and plays apositive role in improving renal function and increasing renal blood perfusion.