Effect of exenatide combined with metformin therapy on insulin resistance, liver function and inflammatory response in patients with type 2 diabetes mellitus combined with NAFLD

摘要

Objective: To study the effect of exenatide combined with metformin therapy on insulinresistance, liver function and inflammatory response in patients with type 2 diabetes mellituscombined with NAFLD. Methods: A total of 98 patients with type 2 diabetes mellituscombined with NAFLD who were treated in the hospital between February 2015 and January2017 were divided into control group and observation group by random number table, eachwith 49 cases. Control group received metformin therapy, and observation group receivedexenatide combined with metformin therapy. Serum levels of insulin resistance indexes, liverfunction indexes and inflammatory factors of two groups of patients were detected beforetreatment and after 12 weeks of treatment. Results: Before treatment, serum levels of insulinresistance indexes, liver function indexes and inflammatory factors were not significantlydifferent between the two groups of patients; after 12 weeks of treatment, serum INS andHOMA-IR levels as well as AST, ALT, GGT, ALP, hs-CRP, IL-1β and IL-6 contents ofobservation group were lower than those of control group. Conclusion: Exenatide combinedwith metformin therapy can effectively reduce insulin resistance, reduce liver function injuryand inhibit systemic inflammatory response in patients with type 2 diabetes mellitus combinedwith NAFLD.