Changes of serum TNF-alpha, IL-2 and IL-13 in patients with rheumatoid arthritis

摘要

Objective: To explore the changes of serum TNF-alpha, IL-2 and IL-13 in patients with rheumatoid arthritis (RA). Methods: A total of 60 patients with rheumatoid arthritis admitted to our hospital from December 2016 to December 2017 were selected as the observation group, and another 60 healthy people in the same period were selected as the control group. Enzyme- linked immunosorbent assay (ELISA) double antibody sandwich method was used to detect the changes of serum TNF-α, IL-2 and IL-13 in the observation group before and after treatment, and was correlated with rheumatoid arthritis disease activity index, plasma ESR, CRP level and DAS28 score. Results: before treatment, serum TNF-α, IL-2 alpha and IL-13 were significantly higher than those in the control group, the observation group of serum TNF-α, IL-2 and IL-13 levels were significantly lower than those before treatment, and compared with the control group, the difference was not statistically significant. Before treatment, the changes of serum TNF-α alpha, IL-2 and IL-13 during the onset of rheumatoid arthritis were positively correlated with the level of plasma ESR, CRP and DAS28. Conclusions: the serum levels of TNF-α, IL-2 and IL-13 in rheumatoid arthritis patients are significantly increased, and are closely related to the activity of rheumatoid arthritis. Patients can be effectively improved after treatment, which is worthy of clinical reference.