Effect of acupuncture combined with drug therapy on the nerve cytokine secretion and oxidative stress in convalescence of cerebral infarction

摘要

Objective: To explore the effect of acupuncture combined with drug therapy on the nervecytokine secretion and oxidative stress in convalescence of cerebral infarction. Methods: Atotal of 118 patients in convalescence of cerebral infarction who were treated in the affiliatedhospital of our school between August 2014 and December 2016 were divided into controlgroup (n=59) and observation group (n=59) according to the random number table method.Control group received routine drug therapy, and the observation group received acupuncturecombined with drug therapy. The differences in serum levels of neurotrophic factors, nerveinjury factors and oxidative stress indexes were compared between the two groups before andafter treatment. Results: The differences in serum levels of neurotrophic factors, nerve injuryfactors and oxidative stress indexes were not statistically significant between the two groupsbefore treatment. After treatment, serum neurotrophic factors IGF-1, BDNF and NGF levels ofobservation group were higher than those of control group; nerve injury factors S-100β, NSE,GFAP and UCH-L1 levels were lower than those of control group; oxidative stress indexesMDA, AOPPs and LHP levels were lower than those of control group while SOD and GSH-Pxlevels were higher than those of control group. Conclusion: Acupuncture combined with drugtherapy can effectively optimize the nerve function, reduce the nerve injury and suppress thesystemic oxidative stress response of patients in convalescence of cerebral infarction.