Clinical significance of coagulation function and plasma cTnI, HCY, PCT levels in the severity and prognosis in patients with acute craniocerebral injury

摘要

Objective: To investigate the relationship between changes of coagulation function and plasmacTnI, HCY, PCT levels and cerebral trauma severity and prognosis in patients with acutecraniocerebral injury. Method: A total of 80 patients with acute craniocerebral injury treated inour hospital from May 2014 to May 2017 were selected as the observation group and dividedinto 3 groups according to the admission GCS score: mild (27 cases), moderate (28 cases) andsevere group (25 cases). 40 healthy volunteers were selected as the control group. The index ofblood coagulation (APTT, PT, Fib, TT, DD) and the levels of cTnI, HCY, PCT in observationgroup after injury and in control group were detected and analysed comparatively. After 1months of treatment, 80 patients were divided into the good prognosis group (54 cases) andpoor prognosis group (26 cases) according to the GOS score and the levels of the parametersabove were detected. Results: (1) The PT, APTT, TT and DD levels of mild, moderate andsevere acute craniocerebral injury groups were higher than those of the control group, butthe level of Fib was lower than that of the control group, and there was also a significantdifference between any two groups respectively. (2) The cTnI, HCY and PCT levels of mild,moderate and severe acute craniocerebral injury groups were higher than those of the controlgroup, and there was also a significant difference between any two groups respectively. (3) Theindexes of PT, APTT and DD in the good prognosis group were lower than those in the poorprognosis group, while the Fib level was higher significantly. (4) The levels of cTnI, HCY andPCT in the good prognosis group were significantly lower than those in the poor prognosisgroup. Conclusion: The levels of coagulation function and plasma cTnI, HCY, PCT in acutecraniocerebral injury patients were correlated positively with the severity and prognosis ofpatients with craniocerebral injury.