Effect of adjuvant nicorandil therapy on inflammation, plaque stability and platelet function in patients with unstable angina

摘要

Objective: To study the effect of adjuvant nicorandil therapy on inflammation, plaque stabilityand platelet function in patients with unstable angina. Methods: A total of 134 patients withunstable angina who received drug therapy in our hospital between March 2015 and March2016 were selected as the research subjects and randomly divided into the experimentalgroup who accepted nicorandil combined with conventional therapy and the control groupwho accepted conventional therapy. 2 weeks after treatment, serum inflammation indexesand plaque stability indexes as well as peripheral blood platelet function parameters weredetermined. Results: 2 weeks after treatment, serum hs-CRP, TNF-毩, IL-18, IL-23, MMP1,MMP2, MMP3, MMP9 and ICTP levels of experimental group were significantly lowerthan those of control group; peripheral blood CD63, PAC-1, CD42b and GP-VI fluorescenceintensity as well as Angle, MA and CI levels of experimental group were significantly lowerthan those of control group while R and K levels were significantly higher than those ofcontrol group. Conclusion: Adjuvant nicorandil therapy can relieve the inflammatory responsein patients with unstable angina, and thereby inhibit the inflammation-mediated fibrous capdegradation, plaque stability decrease, platelet activation and thrombosis.