Effects of budesonide inhalation and montelukast on airway function and serum inflammatory factors in children with asthma

摘要

Objective: To investigate the effect of budesonide and montelukast on airway function andserum inflammatory factors in children with asthma. Methods: A total of 72 children withbronchial asthma were selected as the subjects, and randomly divided into the observationgroup (36 cases) and the control group (36 cases). The children in the control group weretreated with Budesonide Aerosol, and the observation group was treated with montelukastsodium on the basis of the control group. The airway function and the level of inflammatoryfactors were detected and compared between the two groups. Results: Before treatment, therewas no significant difference in TEF25%, TEF50%, TEF75% and FEV1/FVC between the twogroups; After treatment, the TEF25%, TEF50%, TEF75% and FEV1/FVC of the two groupswere improved before treatment, and the indexes in the observation group were higher thanthose in the control group, the difference was statistically significant. Before treatment, theIL-4, IL-6, IL-8, IL-17, TNF- alpha levels in the two groups were not statistically different;After treatment, the levels of IL-4, IL-6, IL-8, IL-17 and TNF- in the two groups were lowerthan those before the treatment, and the indexes in the observation group were lower than thosein the control group, and the differences were statistically significant. Conclusion: Budesonideinhalation combined with montelukast can improve the airway function and inflammatoryfactors in children with asthma.