Effects of lipoic acid on oxidative stress and damages to sensory nerve subgroups in patients with diabetic peripheral neuropathy

摘要

Objective: To explore the effect of lipoic acid on oxidative stress and damages to sensory nerve subsets in patients with diabetic peripheral neuropathy. Methods: A total of 150 patients with diabetic peripheral neuropathy who had received treatment in the Hospital between January 2017 and July 2018 were selected. The patients were randomly divided into two groups, with 75 cases in each group. The control group was treated with Xueshuangtong Injection and Kallikrein, and the observation group was treated with lipoic acid plus medicines given to the control group. The nerve conduction velocity, blood pressure and blood glucose, serum lipids, and serum inflammatory factors were compared between the two groups. Results: The CPT values of the median nerve-ulnar nerves, bilateral superficial peroneal nerves and deep peroneal nerves in the observation group at 5 Hz, 250 Hz, and 2 000 Hz were lower than those in the control group, and the difference was statistically significant. After treatment, the SOD in the observation group was higher than that in the control group, and the MDA and Hs-CRP were lower than those in the control group, where the difference was statistically significant. After treatment, the levels of blood pressure and blood glucose in the observation group were lower than those in the control group, and the difference was statistically significant. After treatment, LDL-C, TC, and TG in the observation group were lower than those in the control group, and HDL-C was higher than that in the control group. The difference was statistically significant. Conclusion: For patients with type 2 diabetes, lipoic acid can help improve the clinical treatment, which can improve the levels of blood glucose, blood pressure and blood lipid, increase nerve conduction velocity, and reduce the damage to sensory nerve subgroup.