Effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy

摘要

Objective: To study the effects of propofol combined with different types of opioids on inflammatory stress response in painless gastroscopy. Methods: Patients who underwent painless gastroscopy in our hospital between August 2014 and January 2018 were retrospectively analyzed, divided into those with nalbuphine hydrochloride, dezocine and sufentanil according to different choice of opioids and included in group A, group B and group C of the study respectively. The contents of inflammatory cytokines and oxidative stress products in serum as well as the expression levels of inflammatory pathway molecules and antioxidant pathway molecules in peripheral blood were measured before and 6 h after gastroscopy. Results: HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH － and O 2 － contents in serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK, ERK1/2, Nrf2, ARE, HO-1, γ-GCS and Prx1 expression in peripheral blood of three groups of patients after gastroscopy were higher than those before gastroscopy, and HMGB-1, TNF-α, IFN-γ, CRP, MDA, OH － and O 2 － contents in serum as well as RhoA, ROCK, Wnt3a, β-catenin, JNK and ERK1/2 expression in peripheral blood of group A after gastroscopy were lower than those of group B and group C whereas Nrf2, ARE, HO-1, γ-GCS and Prx1 expression in peripheral blood were higher than those of group B and group C. Conclusion: Propofol combined with nalbuphine hydrochloride can be more effective than dezocine and sufentanil to reduce the inflammatory stress response in painless gastroscopy.