Effect of adjuvant levocarnitine therapy on EPO resistance, oxidative stress response and inflammatory response in patients with hemodialysis

摘要

Objective: To study the effect of adjuvant levocarnitine therapy on EPO resistance, oxidativestress response and inflammatory response in patients with hemodialysis. Methods: A total of78 patients who received maintenance hemodialysis in Beijing Chaoyang District ShuangqiaoHospital between May 2015 and October 2016 were selected and randomly divided into twogroups, the levocarnitine group received levocarnitine combined with conventional anemiacorrection therapy, and the control group accepted routine anemia correction therapy. Theextent of EPO resistance, oxidative stress response and inflammatory response in two groupsof patients were assessed before treatment as well as 3 months and 6 months after treatment.Results: 3 months and 6 months after treatment, the rhuEPO dosage and ERI, Nrf-2 , ARE,HO-1 and NQO-1 expression in peripheral blood mononuclear cells as well as AOPP, 8-OHdG,MDA, MCP-1, sICAM-1, PTX3, IL-4 and IL-10 levels in serum of levocarnitine group hadbeen gradually decreasing while the rhuEPO dosage and ERI, Nrf-2, ARE, HO-1 and NQO-1expression in peripheral blood mononuclear cells as well as AOPP, 8-OHdG, MDA, MCP-1,sICAM-1, PTX3, IL-4 and IL-10 levels in serum of control group were without significantchange. Conclusion: Adjuvant levocarnitine therapy can significantly improve the EPOresistance, oxidative stress response and inflammatory response in patients with hemodialysis.