Effect of catheter-based renal denervation on left ventricular function, mass and (un)twist with two-dimensional speckle tracking echocardiography

摘要

Background Speckle tracking echocardiography (STE) is an echocardiography modality that is able to measure left ventricular (LV) characteristics, including rotation, strain and strain rate. Strain measures myocardial fibre contraction and relaxation. This study aims to assess the effect of renal sympathetic denervation (RDN) on functional myocardial parameters, including STE, and to identify potential differences between responders and non-responders. Methods The study population consisted of 31 consecutive patients undergoing RDN in the context of treatment for resistant hypertension. Patients were included between December 2012 and June 2014. Transthoracic echocardiography and speckle tracking analysis was performed at baseline and at 6?months follow-up. Results The study population consisted of 31 patients with treatment-resistant hypertension treated with RDN (mean age 64?±?10?years, 15 men). The total study population could be divided into responders ( n ?=?19) and non-responders ( n ?=?12) following RDN. RDN reduced office blood pressure by 18.9?±?26.8/8.5?±?13.5?mmHg ( p ?