首页> 外文期刊>Journal of enzyme inhibition and medicinal chemistry. >Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents
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Kinetic and computational molecular docking simulation study of novel kojic acid derivatives as anti-tyrosinase and antioxidant agents

机译:新型曲酸衍生物作为抗酪氨酸酶和抗氧化剂的动力学和计算分子对接模拟研究

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The novel kojic acid derivatives KAD1 and KAD2 have been demonstrated that they exhibited potent anti-melanogenesis activity in our previous report. In this study, we further study the inhibitory mechanism on mushroom tyrosinase. The inhibitory types of both KADs on diphenolase were classified as mixed type based on the results of the kinetic model. The interaction between KADs and tyrosinase was illustrated by fluorescence quenching, molecular docking and copper chelate activity. The KADs were also evaluated with respect to their antioxidant activities by DPPH and ABTS+ assays. The results showed that KADs have more potent antioxidant activities than kojic acid. Our study could provide new ideas for the development of new anti-tyrosinase and antioxidant agents.
机译:在我们先前的报告中,已证明新型曲酸衍生物KAD1和KAD2表现出有效的抗黑素生成活性。在这项研究中,我们进一步研究了蘑菇酪氨酸酶的抑制机制。基于动力学模型的结果,两种KAD对双酚酶的抑制类型被分类为混合类型。荧光猝灭,分子对接和铜螯合活性说明了KAD与酪氨酸酶之间的相互作用。还通过DPPH和ABTS +分析评估了KAD的抗氧化活性。结果表明,KADs比曲酸具有更强的抗氧化活性。我们的研究可为开发新型抗酪氨酸酶和抗氧化剂提供新思路。

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