Synthesis, spectral characterization, and in vitro antibacterial and antifungal activities of novel 1,3-thiazine-2-amines comprising morpholine nucleus

摘要

A collection of 4-(4-morpholinophenyl)-6-aryl-6 H -1,3-thiazin-2-amines ( 20–28 ) were synthesized and their in vitro antimicrobial activity was investigated. Compound 21 against P. aeruginosa , 23 against B. subtilis , 24 against V. cholerae and P. aeruginosa , 26 against S. aureus and B. subtilis , 27 against B. subtilis and E. coli , and 28 against all tested bacterial strains exerted excellent antibacterial activity. Compound 20 against A. flavus and Rhizopus , 21 , 26 against Rhizopus , 22 , 27 against Mucor , 23 against A. flavus , 24 against both A. flavus and Mucor , 25 against all tested strains, and 28 against Rhizopus and M. gypseum exerted excellent antifungal activity.