Myostatin and Follistatin mRNA Expression inCastrated Rats Submitted to Resistance Training

摘要

Marine DA, Fabrizzi F, Nonaka KO, Duarte ACGO, Leal AMO.Myostatin and Follistatin mRNA Expression in Castrated RatsSubmitted to Resistance Training. JEPonline 2018;21(1):162-171.The purpose this study was to evaluate the influence of resistancetraining on the expression of myostatin and follistatin in castratedrats. Wistar rats were placed under controlled conditions divided intofour groups: (a) castrated trained; (b) intact trained; (c) castratedsedentary; and (d) intact sedentary. The animals trained for 8 wks,climbing a ladder with weights tied to their tail. Myostatin (MSTN)and follistatin (FS) mRNA were quantified by qRT-PCR of the whitegastrocnemius and P≤0.05 were considered statistically significant.MSTN mRNA expression was higher in the castrated sedentary thanthe intact sedentary, the intact trained, and the castrated trained.The expression of FS mRNA decreased in the castrated trainedcompared to the intact sedentary and the intact trained. MSTNexpression increased in the skeletal muscle of castrated rats due tothe absence of testosterone and the influence of training thatpromoted regulation in relation to the castrated sedentary. The FSdecreased with castration and training with difference of trainedcastrated and intact trained, and sedentary intact, and there may beinfluence of other hormones in the absence of testosterone.Resistance training was able to regulate the expression of MSTN inthe castrated group, and reduced the FS gene expression in thesame group. The castration increased the expression of MSTN incastrated sedentary rats.