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首页> 外文期刊>Journal of Diabetes Mellitus >The Level and Role of Interleukin-17 in Patients of Type 2 Diabetes Mellitus with and without Complications
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The Level and Role of Interleukin-17 in Patients of Type 2 Diabetes Mellitus with and without Complications

机译：2型糖尿病伴和不伴并发症患者白细胞介素17的水平和作用

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Background: Type 2 Diabetes Mellitus (T2DM) is the most prevalent metabolic disorder in the world. Recent evidence however suggests that T2DM is not only a disease of metabolism, but also an inflammatory disorder and that inflammation also plays an important role in the pathogenesis of Diabetic complications. Our aim was to study the level of interleukin-17 (IL 17) in Indian populations with T2DM as an inflammatory marker and analyze its role in different diabetic complications. Methods: A total of consecutive 67 patients of T2DM were evaluated for clinical parameters fasting blood glucose (FBG), 2hr-post-prandial blood glucose (PPBG), lipid profile, HbA1c and plasma IL 17. They were divided into three groups—Patients of T2DM without any complications (group A; n = 24), T2DM with acute complications (group B; n = 20), T2DM with chronic complications (group C; n = 23) and compared with 23 healthy controls (group D). Results: Diabetic patients had a higher level of IL 17 as compared to the healthy controls. The level of IL 17 in complicated diabetics was higher than the patients with T2DM without complications. Multiple logistic regression analysis showed positive correlation of IL 17 with Diabetic Retinopathy and Diabetic Neuropathy. IL 17 also showed a positive Pearsons correlation with systolic blood pressure (SBP), diastolic blood pressure (DBP), serum triglycerides (TG), serum total cholesterol (TC), very low density lipoproteins (VLDL), low density lipoproteins (LDL), HbA1c and a negative correlation with HDL. Conclusion: Indian subjects with T2DM with or without complications had higher values of IL 17 as compared to healthy controls. Also diabetic neuropathy and diabetic retinopathy were positively correlated to levels of IL 17. Further levels of IL 17 were positively correlated to hypertension and dyslipidemia indicating a prevalent inflammatory state in our population of T2DM with and without complications.
机译：背景：2型糖尿病（T2DM）是世界上最普遍的代谢性疾病。但是，最近的证据表明，T2DM不仅是一种代谢疾病，而且还是一种炎症性疾病，而且炎症在糖尿病并发症的发病机理中也起着重要作用。我们的目的是研究以T2DM为炎症标记的印度人群中白介素17（IL 17）的水平，并分析其在不同糖尿病并发症中的作用。方法：对连续67例T2DM患者的临床参数进行了评估，包括空腹血糖（FBG），餐后2小时血糖（PPBG），脂质分布，HbA1c和血浆IL17。将患者分为三组-患者没有任何并发​​症的T2DM（A组; n = 24），患有急性并发症的T2DM（B组; n = 20），患有慢性并发症的T2DM（C组; n = 23），并与23名健康对照组进行比较（D组）。结果：与健康对照组相比，糖尿病患者的IL 17水平更高。复杂糖尿病患者的IL 17水平高于无并发症的T2DM患者。多元logistic回归分析显示IL 17与糖尿病性视网膜病变和糖尿病性神经病呈正相关。 IL 17还表现出与收缩压（SBP），舒张压（DBP），血清甘油三酸酯（TG），血清总胆固醇（TC），极低密度脂蛋白（VLDL），低密度脂蛋白（LDL）呈正相关关系，HbA1c与HDL呈负相关。结论：与健康对照组相比，患有或不伴有并发症的印度T2DM受试者的IL 17值更高。糖尿病性神经病和糖尿病性视网膜病也与IL 17水平呈正相关。进一步的IL 17水平与高血压和血脂异常呈正相关，表明我们的T2DM人群中普遍存在炎症状态，有无并发症。

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