Late-Onset Chronic Severe Painless Diarrhea Secondary to Metformin: Case Report and Literature Review

摘要

We present a case of late-onset chronic severe painless diarrhea in an 80-year-old man with type 2 diabetes who was on metformin for 5 years. He underwent multiple laboratory and imaging investigations with no underlying cause found. After detailed medication review, a trial of metformin discontinuation resulted in immediate resolution of symptoms. This case highlights the importance of considering metformin as a cause of new-onset diarrhea in patients even if they had previously tolerated the drug well for years, as its discontinuation can potentially prevent patient inconvenience and discomfort associated with unnecessary investigations.J Endocrinol Metab. 2016;6(1):21-22doi: http://dx.doi.org/10.14740/jem327w