Highly-Controllable Imprinted Polymer Nanoshell on the Surface of Silica Nanoparticles for Selective Adsorption of 17&i&β&/i&-Estradiol

摘要

A highly-controllable core-shell silica-MIPs absorbent by anchoring a MIPs layer to the surface of SiO _( 2 ) nanoparticles via a surface molecular imprinting process was prepared. The templates were covalently modified with functional monomers to form precursor EstSi. The latter together with coupling reagent KH-570, were grafted onto the surface of SiO _( 2 ) nanoparticles before polymerization, to ensure the quantity and quality of imprinted sites on the surface of the covalently attached matrix. The as-synthesized core-shell nanomaterials (SiO _( 2 ) @MIP2) were then evaluated for selective adsorption of 17 β -estradiol (E2) with Raman spectra as detection method. The results indicate that SiO _( 2 ) @MIP2 can fast and selectively adsorb E2 from structural analogues, with detection limit of 0.01 μmol/l.