Enhanced Transport Capabilities via Nanotechnologies: Impacting Bioefficacy, Controlled Release Strategies, and Novel Chaperones

摘要

Emerging nanotechnologies have, and will continue to have, a major impact on the pharmaceutical industry. Their influence on a drug's life cycle, inception to delivery, israpidly expanding. As the industry moves more aggressively toward continuousmanufacturing modes, utilizing Process Analytical Technology (PAT) and ProcessIntensification (PI) concepts, the critical role of transport phenomena becomes elucidated. The ability to transfer energy, mass, and momentum with directed purposeful outcomes isa worthwhile endeavor in establishing higher production rates more economically. Furthermore, the ability to obtain desired drug properties, such as size, habit, andmorphology, through novel manufacturing strategies permits unique formulation controlfor optimum delivery methodologies. Bottom-up processing to obtain nano-sized crystalsis an excellent example. Formulation and delivery are intimately coupled in improvingbio-efficacy at reduced loading and/or better controlled release capabilities, minimizingside affects and providing improved therapeutic interventions. Innovative nanotechnology applications, such as simultaneous targeting, imaging and delivery to tumors, are now possible through use of novel chaperones. Other examples include nanoparticles attachment to T-cells, release from novel hydrogel implants, and functionalized encapsulants. Difficult tasks such as drug delivery to the brain via the blood brain barrier and/or the cerebrospinal fluid are now easier to accomplish.