ANTIFUNGAL ACTIVITY OF THE AQUEOUS AND ETHANOLIC EXTRACTS OF THONNINGIA SANGUINE VAHL. (BALANOPHORACEAE)

摘要

The aim of this study was to evaluate the in vitro antifungal properties of Aqueous and Ethanolic extracts of Thonningia sanguinea Vahl (Balanophoraceae). Thisparasitic plant is commonly used in Ivory Coast and in many other parts of West Africa to treat dermatitis, diarrhea and asthma. Aqueous and Ethanolic extracts of Thonningia sanguine were evaluated for their antifungal activities by double dilution method against three strains: Candida albicans ( C. albicans) Cryptococcus neoformans ( C.neoformans ) and Aspergillus fumigatus ( A. fumigatus) . The phytochemical screening was also evaluated. Antifungal tests indicated that the different extracts studied were active on all selected strains, but their inhibitory activity was more pronounced on C. neoformans compared with A. fumigatus and C. albicans . In addition, our works revealed that the aqueous extract (ATE) was a fungicide on three tested germs while ethanolic extract (ETE) was fungicidal on C. neoformans and fungistatic on the two strains. The phytochemical revealed the presence of alkaloids, tannins and flavonoids. The results showed that the aqueous extract and ethanolic extract of Thonningia sanguine Vahl. (Balanophoraceae) exerted an antifungal effect on C. neoformans, A. fumigatus and C. albicans and supports its traditional use in herbal medicine.