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Nanoparticles: A Novel Approach for Targeted Delivery of Medicines

机译:纳米颗粒:靶向药物的新型治疗方法

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The utilization of nanotechnology in medicine and all the more explicitly tranquilize conveyance is resolved to spread quickly.Right now numerous substances are under scrutiny for medication conveyance and all the more explicitly for disease treatment Strangely pharmaceutical sciences are utilizing nanoparticles to lessen lethality and reactions of medications and up to as of late did not understand that bearer frameworks themselves may force dangers to the patient.The sort of risks that are presented by utilizing nanoparticles for medication conveyance are past that presented by customary perils forced by synthetic concoctions in established conveyance frameworks. For nanoparticles the learning on molecule danger as got in inward breath poisonous quality tells the way the best way to examine the potential risks of nanoparticles. The toxicology of particulate issue contrasts from toxicology of substances as the making chemical(s) could conceivably be dissolvable in natural frameworks, therefore impacting extraordinarily the potential presentation of different inside organs. This may differ from a fairly high neighborhood introduction in the lungs and a low or neglectable presentation for other organ frameworks after inward breath. Be that as it may, ingested species may likewise impact the potential harmfulness of the breathed in particles. For nanoparticles the circumstance is distinctive as their size opens the potential for intersection the different organic boundaries inside the body. From a positive perspective, particularly the possibility to cross the blood cerebrum hindrance may open new ways for medication conveyance into the mind. Likewise, the nanosize additionally takes into consideration access into the cell and different cell compartments including the core. A large number of substances are right now under scrutiny for the arrangement of nanoparticles for medication conveyance, differing from organic substances like egg whites, gelatin and phospholipids for liposomes, and more substances of a concoction nature like different polymers and strong metal containing nanoparticles. This paper gives a diagram on a portion of the right now utilized frameworks for medication conveyance.
机译:纳米技术在医学中的应用以及更明确的镇静输送已被确定为能够迅速传播。目前,许多物质正在接受药物输送的审查,而更明确地用于疾病治疗。奇怪的是,制药科学正在利用纳米颗粒降低药物的致死性和反应性。直到最近,人们还不了解载体框架本身可能会对患者造成危险。利用纳米颗粒进行药物运输所带来的风险已经超过了在现有的运输框架中由合成药物强迫产生的常规危险所带来的风险。对于纳米颗粒,向内呼吸的有毒物质对分子危险性的了解告诉我们检查纳米颗粒潜在风险的最佳方法。颗粒物的毒理学与物质的毒理学形成鲜明对比,因为可以想象到,制造用化学物质可溶于自然骨架,因此极大地影响了不同内部器官的潜在表现。这可能与向肺内较高的邻域引入和向内呼吸后其他器官框架的较低或可忽略的表现有所不同。即便如此,被摄入的物种也可能会影响呼吸颗粒的潜在危害。对于纳米粒子,情况是独特的,因为它们的大小为体内不同有机边界的交叉打开了可能性。从积极的角度来看,特别是穿越血脑障碍的可能性可能会为药物向大脑内输送开辟新的途径。同样,纳米尺寸还考虑了进入细胞和包括核心在内的不同细胞室的通道。目前,对于用于药物输送的纳米颗粒的排列,大量物质正在受到审查,这与有机物质(如蛋清,明胶和脂质体的磷脂)不同,还有更多具有混合性质的物质(如不同的聚合物和含有强金属的纳米颗粒)。本文给出了目前正确使用的药物运输框架的一部分示意图。

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