Formulation Development and Evaluation of Herbal Toothpaste for Treatment of Oral Disease

摘要

Streptococcus mutans is the most common cause of tooth decay. Parabens and other commonly used as anti- Streptococcus agents in toothpaste industry have numerous side effects such as discoloration of teeth. The herbal extract of all three plants gives antimicrobial and anti-inflammatory activity and prevent and reducing the tooth decay, dental caries and given to freshness of mouth. The aim of present work was development and evaluation of herbal antimicrobial toothpaste containing Bark of Acacia nilotica, Acacia catechu and flower buds of syzygium aromaticum as herbal ingredients. Different types of formulations (F1-F6) were formulated using calcium carbonate as abrasive and Glycerine as humectant in varied concentrations. All the formulations were evaluated for various parameters like dryness, color, appearance, consistency, washability, pH, spreadability and foaming power. Polyherbal toothpaste containing hydroalcoholic extract of plants was tested for antimicrobial activity against Staphylococcus aureus and Streptococcus mutans with different concentrations of toothpaste were used (25, 50and 100 mg/ml). Among the tested bacteria used Staphylococcus aureus was found to be most sensitive to the formulated toothpaste as seen by zone of inhibition (19-24 mm) followed by Streptococcus mutans (13-18 mm). The results showed that the formulated polyherbal toothpaste is promising antimicrobial effects against both organisms. It may be safer compared to fully synthetic toothpaste. Further studies are warranted to prove safety and efficacy of the formulated polyherbal toothpaste.