FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ATAZANAVIR SULPHATE CONTROLLED RELEASE NON-EFFERVESCENT FLOATING MATRIX TABLETS

摘要

The objective of the present work to develop extended-release floating matrix tablets of ATZ, which were designed to prolong the gastric residence time and drug release after oral administration. Different grades of low-density lipid (i.e. ethylcellulose) and Hydroxypropyl methylcellulose (i.e. HPMC K100M) were used to get the desired floating and prolonged release profile over an extended period. All the formulations extended the drug release up to 24 hours and more and the formulations were optimized for the desired release profiles. The release and floating property depended on the polymer type and polymer proportion. The formulation prepared with EC and HPMC K100M (i.e. 10%, 20%, and 30%) has more floating time than the formulation prepared with the EC alone. The optimized formulation (F10) prepared with a combination of EC N100 and HPMC K100M was evaluated for In vivo radiographic study, which shows the floating property for up to 9 hours. The DSC study shows that there is no drug-polymer interaction. This study gives the preliminary idea about the development of the floating drug delivery systems of Atazanavir without the use of a gas generating agent.