Isolation and Characterization of Aegle marmelos Gum– A Novel Controlled Release Polymer

摘要

Wide ranges of drugs are formulated now in a variety of different forms for oral extended-release dosage forms. However, only those which result in a significant reduction in dose frequency and/or a reduction in toxicity resulting from high concentration in the blood or gastrointestinal tract are likely to improve therapeutic outcomes. To be a successful extended-release product, the drug must be released from the dosage form at a predetermined rate, dissolve in the gastrointestinal fluids, maintain sufficient gastrointestinal residence time, and may be absorbed at a rate and will replace the amount of drug being metabolized and excreted. In a nut shell, controlled-release formulations are a promising way to improve the patient’s compliance by reducing dosing intervals and minimizing adverse effects. Out of many approaches to controlled drug release, matrix based approach is widely used due to its simplicity, scalability and from stability point of view. In order to control the release of drug from its dosage form, an effective controlled release polymer is essential. Though, there are several controlled release polymers available in the market, there is continuous need to develop controlled polymers which are safe and inexpensive. The aim of the work was to isolate and characterize the aegle marmelos gum as novel controlled relase polymer.