Design, Development, Characterization and in-vitro Evaluation of Medicated Chewing Gum: Granisetron Hydrochloride

摘要

Medicated Chewing Gums are mobile drug delivery systems. It is a potentially useful means of administering drugs either locally or systemically via, the oral absorption. The medicated chewing gum has through the years gained increasing acceptance as a drug delivery system. e.g. Aspirin as an analgesic, Chlorhexidine as local disinfectant, Fluoride for prophylaxis of dental caries, Nicotine for smoking cessation, Caffeine as a stay alert preparation and Dimenhydrinate as antiemetic drugs etc. MCGs are solid, single dose preparations with a base consisting mainly of gums that are intended to be chewed but not swallowed. They contain one or more active substances which are released by chewing and are intended to be used for local treatment of mouth diseases or systemic delivery after absorption through the buccal mucosa and improve the oral bioavailability of drugs undergoing first pass metabolism.