Insulin Pump Therapy in Adolescents With Very Poor Glycemic Control During a 12-Month Cohort Trial

摘要

Adolescence is a challenging time for managing diabetes,with recent data from the type 1 diabetes (T1D) exchangehighlighting teenagers have the highest risk of poor glycemiccontrol.1 Insulin pump therapy (CSII) is a standard treatmentmodality for patients with type 1 diabetes but caution in theuse of CSII therapy in this group stems from the potential formetabolic decompensation to diabetic ketoacidosis becauseof the sole use of rapid acting insulin, or secondary to experience bias that is in conflict with published data supportingthe use of CSII.2,3 To evaluate the safety and efficacy of CSIIin adolescents (aged 14-17 years) with T1D for > 1 year,insulin pump na?ve and with very poor glycemic control(defined for this study as an average HbA1c >10.0% in thepreceding 6 months) we conducted a prospective cohortstudy over a 12-month period (ACTRN12614001198617,ethics approved by Princess Margaret Hospital HealthResearch Ethics Committee [201407EP]).