LIQUISOLID TECHNIQUE AS A PROMISING TOOL TO ENHANCE SOLUBILITY AND DISSOLUTION OF POORLY WATER SOLUBLE DRUG VALSARTAN

摘要

“Liquisolid Technique” considered as new technique to enhance solubility and dissolution rate of poorly water soluble drugs. These formulations are prepared by mixing drug in liquid state (solution, suspension or emulsion using non-volatile solvent) with carrier and coating material to form dry, free-flowing, readily compressible powder. In the current research work liquisolid technique is employed to enhance solubility and dissolution of antihypertensive drug Valsartan, which is poorly water soluble (0.021mg/ml) possessing very low bioavailability of 23%. Liquisolid formulation VLS9, containing Tween 80 (non-volatile solvent), Avicel PH102 (carrier) and Aerosil 200 (coating material) showed better flow properties and high in-vitro dissolution profile.