Multiple genetic variants associated with posttransplantation diabetes mellitus in Chinese Han populations

摘要

Objectives Posttransplantation diabetes mellitus (PTDM) is a major complication after solid organ transplantation. This study is to investigate the association of nine genetic variant factors and PTDM in Chinese Han patients. Methods HLA‐DP (rs3077, rs9277535), HLA‐DQ (rs7453920), signal transducer and activator of transcription 4 (STAT4) (rs7574865), IL‐28B (rs12979860, rs8099917, and rs12980275), and IL‐18 (rs1946518 and rs187238) were investigated in 260 liver transplant recipients (PTDM vs non‐PTDM) by high‐resolution melting curve analysis. Serum interleukin (IL)‐1β, IL‐6, IL‐8, IL‐17, interferon‐γ, inducible protein‐10, monocyte chemoattractant protein‐1, and macrophage inflammatory protein‐1b were analyzed by a Bio‐Plex suspension array system (Bio‐Plex Multiplex Immunoassays, Bio‐Rad, Hercules, CA, USA). Results Signal transducer and activator of transcription 4 (rs7574865) T allele and IL‐18 (rs1946518) A allele increase the risk for insulin resistance and PTDM. Conclusions Recipients with STAT4 (rs7574865) T allele are associated with an increased concentration of IL‐1β, interferon‐γ, monocyte chemoattractant protein, and macrophage inflammatory protein‐1b. The genetic variants of STAT4 (rs7574865) and IL‐18 (rs1946518) may be new important markers for PTDM.