Synthesis of spiro[pyrazolo[3,4-e?‘?] pyridine-4,3'-indoline] and spiro [benzo[a??]pyrazolo[3,4-e?‘?]quinoline-4,3'-indoline] derivatives using wet cyanuric chloride under solvent-free conditions

摘要

A simple and efficient synthesis of spiro[pyrazolo[3,4-e?‘?]pyridine-4,3'-indoline] and spiro[benzo[a??] pyrazolo[3,4-e?‘?]quinoline-4,3'-indoline] derivatives has been accomplished by the one-pot condensation of isatins, 3-methyl-1-phenyl-1e???-pyrazol-5- amine and Meldruma€?s acid or 2-hydroxy-1,4-naphthoquinone in the presence of wet cyanuric chloride as a catalyst under solvent-free conditions.