High prevalence of diabetes and abnormal glucose tolerance in Thai women with previous gestational diabetes mellitus

摘要

Highlights ? Eighty-one percent of pGDM women developed AGT within 4 years after delivery. ? First risk factors for AGT was PG ≥ 150 mg/dl at 1 h after a 50 g-GCT. ? Second risk factors was ≥3 abnormal PG values in a 100 g-OGTT . Abstract Aim To determine the prevalence of and risk factors for abnormal glucose tolerance (AGT) in previous gestational diabetes mellitus (pGDM) women . Methods 100 pGDM women randomly selected from the database of the Department of Obstetrics/Gynecology. 75 g-OGTT were performed in subjects without known diabetes. AGT was diagnosed using the American Diabetes Association criteria. Results The mean age, pre-gestational BMI, and time since delivery were 38 ± 5 years, 24.5 ± 5.7 kg/m 2 , and 46 ± 26 months. Overall, 81% of the subjects had AGT, including IGT (38%), IGT + IFG (5%), T2DM (38%). Plasma glucose ( PG) at 1 h after a 50 g-glucose challenge test (GCT) , PG at 1 h after 100 g-OGTT, HbA 1c , and HOMA-IR were significantly greater in women with AGT than normal glucose tolerance (NGT) women. The proportion of women with ≥3 abnormal PG values during 100 g-OGTT was greater in AGT than NGT group (50.7% vs. 15.8%). Multivariate analysis showed that PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in 100 g-OGTTs were risk factors for developing AGT. Conclusions Eighty-one percent of pGDM women developed AGT within 4 years after delivery. Risk factors for AGT were PG ≥ 150 mg/dl at 1 h after a 50 g-GCT and ≥3 abnormal PG values in a 100 g-OGTT.