Effect of epirubicin on mitotic index in cultured L-cells

摘要

Cancer chemotherapy is an additional application to surgical operations and radiotherapy in the treatment of widespread tumors. An anthracycline-derived antibiotic, epirubicin (EPI) is one of the clinically used antineoplastic drugs. In this study the cytotoxic effects of EPI in transformed mouse fibroblasts (L-cell) were examined. EPI concentrations of 0.001 |ìg/ml, 0.01 |ìg/ml and 0.1 |ìg/ml were applied to the cells for 2, 4, 8, 16 and 32 hours. The results showed that EPI diminished mitotic index of L-cells depends upon time and applied concentrations. This decrease was found statistically significant in each treatment group when compared to control (p<0.05 - p<0.001).