Supersaturated Calcium Phosphate Rinse vs. Standard of Care for Mitigating Mucositis in Head and Neck Chemoradiation

摘要

>Introduction:>> style="font-family:""> style="font-family:Verdana;"> Oral mucositis (OM) can have a significant impact on patients’ quality of life, pain and treatment costs. Almost all patients receiving head and neck chemoradiation develop OM. style="font-family:Verdana;">Patients and Methods: style="font-family:Verdana;"> Twenty patients were evaluated retrospectively for OM when undergoing head and neck chemoradiation. The control, soda/salt rinse, was compared to a powdered supersaturated calcium phosphate rinse (SSCPR), SalivaMAX. style="font-family:Verdana;">Results: style="font-family:Verdana;"> The SSCPR group experienced a delay in the onset of OM, which was not statistically significant, and a marked reduction in peak OM that was statistically significant ( style="font-family:Verdana;">p style="font-family:Verdana;"> > 0.001). style="font-family:Verdana;">Conclusion: style="font-family:Verdana;"> This retrospective study demonstrates that a powdered SSCPR is a safe and effective method of oral mucositis mitigation.