Owing to their radical scavenging nanoparticles (CeO2-NPs) are currently used for various applications, including drug delivery or alternative chemotherapy agents. In this paper, the cellular uptake and cytotoxicity caused by small size CeO2-NPs (20-nm) on cultured human lung cancer cells was evaluated. The MTT assay was used to assess cell viability after 24h exposure to 0 to 250 ug/ml of CeO2-NPs. The results showed a dose dependent and exposure time decreased of cell viability. Cellular uptake was confirmed by the conjugation of CeO2-NPs with a fluorescent dye rhodamine- 6G using confocal microscopy.
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机译：由于其自由基清除纳米颗粒（CeO2-NPs）目前用于各种应用，包括药物递送或替代化疗药物。本文评估了小尺寸CeO2-NPs（20 nm）对培养的人肺癌细胞的细胞摄取和细胞毒性。在暴露于0至250 ug / ml CeO2-NPs 24小时后，MTT分析用于评估细胞活力。结果表明剂量依赖性和暴露时间降低了细胞活力。通过使用共聚焦显微镜将CeO2-NPs与荧光染料若丹明6G结合来确认细胞摄取。
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