首页> 外文期刊>Journal of biosciences >Translesion DNA polymerases Pol e???, Pol e???, Pol e???, Pol e??… and Rev1 are not essential for repeat-induced point mutation in Neurospora crassa
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Translesion DNA polymerases Pol e???, Pol e???, Pol e???, Pol e??… and Rev1 are not essential for repeat-induced point mutation in Neurospora crassa

机译:Translesion DNA聚合酶Pol e ???,Pol e ???,Pol e ???,Pol e ??…和Rev1对于重复诱导点孢菌的点突变不是必需的

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Pol e???, Pol e???, Pol e???, Pol e??… and Rev1 are specialized DNA polymerases that are able to synthesize DNA across a damaged template. DNA synthesis by such translesion polymerases can be mutagenic due to the miscoding nature of most damaged nucleotides. In fact, many mutational and hypermutational processes in systems ranging from yeast to mammals have been traced to the activity of such polymerases. We show however, that the translesion polymerases are dispensable for repeat-induced point mutation (RIP) in Neurospora crassa. Additionally, we demonstrate that the upr-1 gene, which encodes the catalytic subunit of Pol e???, is a highly polymorphic locus in Neurospora.
机译:Pol e-,Pol e-,Pol e-,Pol e-…和Rev1是专门的DNA聚合酶,能够在受损模板上合成DNA。由于大多数受损核苷酸的错误编码性质,通过这种跨病变的聚合酶进行的DNA合成可能是诱变的。实际上,从酵母到哺乳动物的系统中的许多突变和超突变过程都可以追溯到这种聚合酶的活性。但是,我们显示,跨病灶聚合酶对于Neurospora crassa中的重复诱导点突变(RIP)是可有可无的。另外,我们证明了编码Pol e-的催化亚基的upr-1基因是神经孢子虫中的高度多态性基因座。

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