Role of serum chemerin level in atherosclerosis in Egyptian patients with Type 2Diabetes Mellitus

摘要

Vascular diseases, particularly atherosclerosis, are major causes of disability and death in patients with diabetes mellitus. Chemerin is a novel adipokine that is highly expressed in obese and insulin-resistant subjects. Chemerin may play an important role in linking metabolic syndrome and inflammation. The study was conducted to determine serum chemerin levels in diabetic patients, and its relation to BMI, disease duration, and CRP, also to assess the role of serum chemerin level in atherosclerosis. A total of 40 Egyptian patients with type 2 diabetes mellitus (20 diabetics without hypertension, 20 diabetics with hypertension), and 15 age and sex matched healthy control subjects were included in this study. Serum chemerin level was determined by ELIZA. Its level was compared between both diabetic patients and controls, between dyslipidemic and non-dyslipidemic patients, and between diabetic patients with hypertension and those without hypertension. Also to detect the correlation of serum chemerin level with CRP, BMI; also to assess the relation of carotid intima media thickness (CIMT) to chemerin level. There was statistically highly significant increase in mean serum chemerin in diabetic patients (316.34±92.85 ng/ml) compared with control group (130.56± 19.52 ng/ml) (P: 0.000). Chemerin level was not significantly correlated with BMI, CRP, FBG,2 hours postprandial blood glucose, lipid profile. There was a statistical significant increase in mean right and mean left carotid intima media thickness in diabetic patients (0.08 ± 0.02cm, 0.09 ± 0.019 respectively) compared with the control group (0.07 ± 0.12, 0.06± 0.01) (P:0.008, 0.000 respectively). There was highly significant increase in mean serum chemerin level in diabetic patients with hypertension (399.35 ± 72.0) compared with the diabetic patients without hypertension (234.6 ± 63.95) (P: 0.000). There was also no statistical significant difference in serum chemerin level between dyslipidemic diabetic patients and non dyslipidemic diabetic patients (P > 0.05). Conclusion: High levels of serum chemerin in our diabetic patients indicate the activation of immune response in these patients. High carotid intimal media thickness in diabetic patients was not related to chemerin denoting an underlying combining factor for atherosclerosis in diabetic patients other than chemerin. High chemerin in diabetic hypertensive patients denote additive role of hypertension to diabetic in beginning of immune response in those patients