International Scientific Acupuncture and Meridian Symposium 2013

摘要

The brain-body system aims to maintain the homeostasis of the internal milieu. The goal of the human brain-body system isalso to maintain the milieu of “psychic homeostasis”, an autoregulated state of well-being, to maintain a dynamic balancewithin the psychic sphere. The hypothalamus and the nucleus tractus solitarius region are well-known to play an importantrole in the brain-body system and to interact reciprocally. The use of these key regions for brain-body medicine is madepossible through the balanced integration of volume transmission and synaptic transmission in neuronal-glial networks. Thereceptor-receptor interactions in heteroreceptor complexes present at synaptic and extra-synaptic locations, together withthe endocrine signals, play an important role in this integrative process. The new field of brain-body medicine builds onneuroimaging with fMRI and PET and, based on correlative studies, gives strong support for the participation of corticalregions, especially prefrontal regions, in the regulation of endocrine, immune and autonomic responses via the medialprefrontal brain-stem axis. A link exists between heart rate and anxiety. The b-adrenergic receptor agonist isoproterenol ata dose that has no direct effects on the CNS produced increases in the blood stream of extracellular vesicles, which maycontribute to the isoproterenol-induced anxious behavior and may represent a novel peripheral signal, besides the visceralsignals, modulating psychic homeostasis.