Assessment of the Antiulcer Potential of Moringa oleifera Root-Bark Extract in Rats

摘要

In the present study, an ethanolic root-bark extract ofMoringa oleifera(MO) was examined for its antiulcer potential in albino Wistar rats using two experimental models: ethanol-induced and pylorus ligation-induced gastric ulceration. The extract was orally administered at three different doses (150, 350, and 500?mg/kg) for 15 consecutive days. The antiulcer effects in rats treated with different doses of the extract and omeprazole (30?mg/kg, p.o.) were determined and compared statistically with the antiulcer effects in the control rats treated with saline (NaCl, 0.9%). The MO at doses of 350 and 500?mg/kg decreased the ulcer index significantly as compared to the control group (p?