To Compare The Safety & Efficacy of Loteprednol Etabonate 0.5% & Prednisolone Acetate 1% in the Post-operative Inflammation Following Cataract Extraction with Intraocular Lens Implantatio

摘要

To compare the mean rise in intraocular pressure and post-operative inflammation between loteprednol etabonate 0.5% and prednisolone acetatae1%. Out Patient Department of Ophthalmology Depart- ment, Government Medical College, Jammu. Comparative case series. Patients aged 18 years and older undergoing cataract surgery were divided into two groups: Group A (n=100) was prescribed loteprednol etabonate 0.5% (LE) four times a day; Group B (n=100) was prescribed prednisolone acetate 1% (PA) four times a day. Patients with pre-existing medical conditions like raised intraocular pressure, maculopathy, uveitis, retinopathy were excluded. Intraocular pressure and post-operative inflammation were assessed over 42 days after cataract surgery. Loteprednol etabonate 0.5% (LE) and prednisolone acetate 1% (PA) were equally efficacious in decreasing Anterior Chamber cells (0.08±0.27 vs 0.05±0.22 respectively; p=0.39) and Anterior Chamber flare (0.06±0.24 vs 0.05±0.22 respectively; p=0.76) at 42 days. There was statistically significant difference in intraocular pressure at 42nd days with LE as compare to PA(16.21±3.34 vs 18.62±2.36 respectively; p0.001). The equiva- lent control of inflammation can be obtained through treatment with LE and PA after cataract surgery but the mean rise in intraocular pressure in patients treated with loteprednol etabonate is less than in patients treated with prednisolone acetate.