Endothelin Dissociates Muscle Tension from Cytosolic Ca2+ in Vascular Smooth Muscle of Rat Carotid Artery

摘要

References(10) Cited-By(8) Endothelin induced rapid increase followed by a decrease in cytosolic Ca2+ ([Ca2+]i) and a slow increase in muscle tension in the vascular smooth muscle strip of rat carotid artery. Thus, the endothelin-induced contraction was smaller, and it, became gradually greater than high K-induced contraction at a given [Ca2+], i. In Ca2+-free solution, endothelin induced a transient increase in [Ca2+]i and a sustained contraction. These results suggest that endothelin-induced contraption is due to the increase in [Ca2+]i, the time-dependent change in Ca2+-sensitivity of contractile elements, and the mechanism which is independent of the increment in [Ca2+]i.