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首页> 外文期刊>Japanese Journal of Pharmacology >Ethanol Inhibits Vestibular and Caloric Nystagmus without Affecting Optokinetic Nystagmus in Rabbits
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Ethanol Inhibits Vestibular and Caloric Nystagmus without Affecting Optokinetic Nystagmus in Rabbits

机译:乙醇抑制前庭和热量性眼球震颤,而不影响家兔视动眼球震颤

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摘要

References(22) Cited-By(1) Effects of ethanol on optokinetic, vestibular and caloric nystagmus were investigated in pigmented rabbits to determine whether or not it affects a specific site involved in the induction of various nystagmus. Optokinetic nystagmus was produced by rotation of the drum with vertical stripes at an angular velocity of 0.85°/sec. Vestibular nystagmus was induced by horizontal rotation at an angular velocity of 30°/sec and caloric nystagmus by infusion of cold water into the external meatus. Cumulative injection of ethanol into the auricular vein to doses of 0.1, 0.2, 0.4 and 0.8 g/kg inhibited both vestibular and caloric nystagmus dosedependently, but did not affect the optokinetic nystagmus. These results suggest that relatively low doses of ethanol mainly act on the peripheral vestibular organ and impair the vestibular function without affecting the optokinetic system.
机译:参考文献(22)引用了(1)研究了有色兔子中乙醇对视动,前庭和热量性眼球震颤的影响,以确定其是否影响诱导各种眼球震颤的特定部位。通过以0.85°/秒的角速度旋转具有垂直条纹的鼓来产生视动性眼球震颤。通过以30°/秒的角速度水平旋转来诱发前庭眼球震颤,并通过将冷水注入外耳道来引起热量性眼球震颤。以0.1、0.2、0.4和0.8 g / kg的剂量向耳静脉内累积注射乙醇可剂量依赖性地抑制前庭和热量性眼球震颤,但不影响视动眼球震颤。这些结果表明,相对低剂量的乙醇主要作用于外周前庭器官并损害前庭功能,而不影响光动力系统。

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