EFFECTS OF 1-MORPHOLINOACETYL-2-METHYL-3-PHENYL-4-OXO-1, 2, 3, 4-TETRAHYDRO QUINAZOLINE HYDROCHLORIDE (HQ-275) ON α-NAPHTYL ISOTHIO-CYANATE- AND/OR THIOACETAMIDE-INDUCED LIVER DAMAGE IN RATS

摘要

References(19) Pharmacological properties of 1-morpholinoacetyl-2-methyl-3-phenyl-4oxo-1, 2, 3, 4-tetrahydro quinazoline hydrochloride (HQ-275), which has a potent choleretic activity, on ANIT and TAA-hepatic injury have been investigated in rats for biochemical, histochemical levels and the functions in the liver. Regarding the actions of biliary and solid content excretion, HQ-275 demonstrates differences between normal rats and the groups administered ANIT and/or TAA, and also the lowered values of Al-P, transaminases and bilirubin in plasma, elevated by the ANITpoisoning. Thus a comparable effect of HQ-275 against TAA-poisoning was not observed. TAA-induced elevation of the plasma-lipid level was significantly prevented by the administration of HQ-275. Moreover, under light microscopical examination, the decrease of 5'-N by the ANIT-poisoning was prevented even with small doses of HQ-275 3-6 mg/kg, p.o. Elevation of the cholesterol level in plasma and decrease of ATP-ase in histochemical findings by ANIT-intoxication were not in themselves recognizable. Changes of Na+ and K+ in bile and water content of liver by poisoning of ANIT were clearly prevented with HQ-275. On the other hand, HQ-275 revealed no effects on the actions produced by TAA-intoxication except for those mentioned. Such being the case it can be concluded that HQ-275 inhibits the ANIT-induced hepatic injury to a greater extent than the TAA-induced hepatic damage for biochemical and histochemical levels.