Synthesis of some uracil derivatives using ionic liquid

摘要

In the present study, some 3-(substituted phenyl)-2, 10-dihydro-10-oxo-1-thioxo-1Hpyrimido[6, 1-b] quinazoline-4-carbonitriles were prepared from 6-(substituted phenyl)-1,2,3,4-tetrahydro- 4-oxo-2-thioxopyrimidine-5 carbonitriles. The synthesis involved three steps. The first step was one pot condensation of thiourea with substituted benzaldehydes in alcohol using potassium carbonate as catalyst to give uracils (TSI –TSIV). These uracils were then converted to the compounds, 4-chloro-1, 2-dihydro-6-substituted phenyl-2-thioxopyrimidine-5-carbonitrile (TSIa- TSIVa) by overnight stirring of with POCl3 using DMF as solvent. Later on the title compounds, quinazoline derivatives (T1-T4) were prepared in one step by reacting (TSIa-TSIVa) with anthranilic acid in DMSO using catalytic amount of ionic liquid (1-n-butylimidazolium chloride). The structures of newly synthesized compounds (T1-T4) have been confirmed on the basis of spectral data.