Convenient synthesis of thiazole derivatives grouping with pyrazole ring under the microwave

摘要

Here in, we have synthesised the series of pyrazole bearing thiazole derivatives and optimized the solvent, reaction time and % yield in microwave assisted as well as conventional method. The reaction of 4-substituted phenacylbromide with thioamide using piperidin as a catalyst and methanol as a solvent yielded series of substituted thiazole(7a-h). After obtaining experimental data concerning the yield and the time taken for the synthesis by both the methods, conventional and microwave assisted method, it was proved that the microwave assisted method is convenient for synthesis of new series of 2-(2-((3-(3-nitrophenyl)-1-phenyl-1H-pyrazol-4-yl) methylene) hydrazinyl) -4-sustituted phenyl-2, 5-dihydrothiazole [7a-h]. The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1 H NMR, 13C NMR.