Association of Interleukin-1 Gene Polymerphism and Multiple Sclerosis

摘要

Background: Elevated interleukin-1b (IL-1b) level is a proinflammatory cytokine involved in neuronal injury of multiple sclerosis (Ms) and IL-1b genetic polymorphism is reported to be associated with elevated IL-1b. Objective: To study the relation between IL-1b as well as IL 1-b gene polymorphism and multiple sclerosis. Methods: Twenty seven relapsing remitting multiple sclerosis patients and twenty-five normal subjects were included in this study. Patients were evaluated clinically and radiologically. Laboratory investigations, IL-1b assay and genetic testing of IL-1b gene were done for both patients (during and between attacks) and control groups. Results: Serum IL-b level was significantly high in multiple sclerosis patients (during and between attack) compared to control subjects and high IL-1b level was significantly associated with female patients. No statistically significant results associated with severity, age of onset and MRI lesions. In human IL-b-511 gene polymorphism genotype, there is no significant difference of IL-1b serum concentration regarding IL-1b-511 gene polymorphism. Conclusion: IL-1b level is elevated in multiple sclerosis patents and considered as a biomarker. Human IL-1b-511 polymorphism did not influence the serum level of IL-1b and did not show any associated with multiple sclerosis. [Egypt J Neurol Psychiat Neurosurg.  2014; 51(1): 45-51]