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Nailfold capillaroscopic changes in Egyptian patients with psoriatic arthritis in comparison to rheumatoid arthritis

机译:与类风湿关节炎相比,埃及银屑病关节炎患者的鼻腔毛细血管镜变化

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IntroductionNailfold capillaroscopy (NFC) is simple technique for assessment of the microvascular changes recognized in both diseases can be used in helping the differential diagnosis.Aim of the workTo determine the nailfold capillaroscopic changes in psoriatic arthritis (PsA) and rheumatoid arthritis (RA) patients and their relation to disease activity.Patients and methodsTwenty PsA and 20 RA patients were studied. Disease activity score (DAS28) was assessed. NFC examination was done to all patients.ResultsThere was a significant decrease in capillary density (8.65?±?1.39 vs 9.5?±?1/mm; p?=?0.02) and increase in mean capillary width (28.4?±?7.8?μm vs 22.9?±?4.3?μm; p?=?0.01) in PsA than RA patients. Hairpin, organized capillaries were found in all RA patients while in PsA patients tortuous capillaries were found in 100% and disorganized capillaries in 35%. A significant increase in hemorrhages (65% versus 10%; p?
机译:简介折叠式毛细血管镜(NFC)是一种评估两种疾病中公认的微血管变化的简单技术,可用于帮助鉴别诊断。工作的目的是确定银屑病关节炎(PsA)和类风湿性关节炎(RA)患者的折叠式毛细血管镜变化以及患者和方法研究了20例PsA和20例RA患者。评估疾病活动评分(DAS28)。结果所有患者均进行了NFC检查。结果,毛细血管密度显着降低(8.65±±1.39 vs 9.5±±1/1 / mm;p≥= 0.02),平均毛细宽度增加(28.4±±7.8)。与RA患者相比,PsA的μm与22.9?±?4.3?μm; p?=?0.01)。在所有RA患者中均发现了发夹状,有组织的毛细血管,而在PsA患者中,有100%的患者呈曲折性毛细血管,而有35%的患者则存在无组织的毛细血管。与RA患者相比,PsA出血量显着增加(65%比10%; p 0.0001)。在PsA患者中,嫩关节数(TJC)与毛细血管宽度(r?=?0.44,p?=?0.047)之间显着相关,与毛细血管密度(r?=?0.46, p≥0.04)。 TJC与毛细血管紊乱显着相关(p≤0.035)。 CRP滴度与毛细血管动脉直径之间呈显着负相关(r?=?0.45,p?=?0.045)。结论RA患者的指甲折叠毛细血管镜检查无特异性变化,而PsA患者的密度低,扩张,弯曲和毛细血管混乱和出血。因此,可采用Nailfold毛细血管镜在两种疾病之间进行区分。 NFC异常可能与疾病活动有关。

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