Clinical utility of left ventricular strain, wall stress and serum brain natriuretic peptide levels in chronic hemodialysis patients

摘要

BackgroundLeft ventricular (LV) global longitudinal strain (GLS) reliably assesses LV systolic function. The precise relation between LV wall stress and serum Brain natriuretic peptide (BNP) concentrations in hemodialysis (HD) patients needs to be clarified. BNP levels are raised in patients with end-stage renal disease (ESRD) and could reflect LV impairment among HD patients.Aim of this workThis study sought to evaluate the clinical utility of LV-GLS, wall stress and serum BNP levels in chronic HD patients. The correlations between BNP levels with both LV wall stress and LV-GLS were assessed.Patients and methods30 ESRD patients on regular HD {categorized into 15 patients with LV ejection fraction (EF)?≤?50% and 15 patients with LV EF?>?50%} and 15-age matched healthy subjects were included. LV function and structure were assessed by conventional echocardiography including LV meridional wall stress (LVMWS), LV mass index (LVMI) and 2-dimensional speckle tracking echocardiography for determination of LV-GLS. Serum BNP levels were evaluated after HD session.ResultsThere were significant increase of LVMSW (189.2?±?81 vs. 72.2?±?20.6?dynes/cm2?×?1000, P??50%. Serum levels of BNP were positively correlated with LVMI (r?=?0.896, P?