The waist circumference-adjusted associations between hyperuricemia and other lifestyle-related diseases

摘要

BackgroundFew studies have assessed the associations between hyperuricemia and lifestyle-related diseases after adjusting for waist circumference (WC) and sex. MethodsThis cross-sectional study included 33,498 Japanese individuals, and was conducted at the Center for Preventive Medicine, NTT Kanto Medical Center, Tokyo, from May 2006 to March 2015. Hyperuricemia was defined as a uric acid level of?>7?mg/dl in men;?>6?mg/dl in women. Metabolic syndrome (Mets) components were defined using the Japanese criteria for Mets. The subjects were stratified into quartiles according to their WC as follows: males: ResultsHyperuricemia was found to be an independent predictor of lifestyle-related diseases after adjusting for age, WC, and lifestyle in both sexes. Males: a uric acid level of?>7?mg/dl (odds ratio [OR]: 1.70, 95% confidence interval [CI]: 1.57–1.83), Females: a uric acid level of?>6?mg/dl (OR: 2.35, 95% CI 1.83–2.99). ConclusionHyperuricemia was found to be an independent predictor of several lifestyle-related diseases, even after adjusting for WC which is closely related with insulin resistance. Hyperuricemia might require greater attention during the prevention of lifestyle-related diseases and future cardiovascular disease.